(E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine → Methyl 3-methoxybenzoate

HRID 1609340

반응식

HRID 1609340 반응식
C1(C2N=C(/C=C/C3C=C(N)C=CC=3)SC=2)CCC1.[CH3:19][O:20][C:21](=[O:34])[C:22]1[CH:27]=[CH:26][C:25](CC(O)=O)=[C:24]([O:32][CH3:33])[CH:23]=1>C(Cl)Cl>[CH3:19][O:20][C:21](=[O:34])[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([O:32][CH3:33])[CH:23]=1

참가 물질

4

반응물 2

HCID 15136086(E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamineHCID 542548432-Methoxy-4-methoxycarbonyl-phenylacetic acid

생성물 1

HCID 79332Methyl 3-methoxybenzoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution composed of 0.49 g of (E)-3-[2-[4-(cyclobutyl)-2-thiazolyl]ethenyl]benzeneamine, 0.43 g of 4-carboxymethyl-3-methoxybenzoic acid methyl ester, 0.4 g of N-ethyl-N-(dimethylaminopropyl)carbodiimide and 25 ml of methylene chloride was sealed in a flask and stored at 25° C. for 16 hr. The reaction mixture was then washed with 10 ml of water, dried (MgSO4) and the solvent removed by rotary evaporation. The residual material was purified by silica gel chromatography using ethyl acetate as the eluant to yield 0.62 g of (E)-4-[2-[3-[2-(4-cyclobutyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]-3-methoxybenzoic acid methyl ester; m.p., 156°-157° C. from ethyl acetate.

후처리

  1. customwas sealed in a flask
  2. washThe reaction mixture was then washed with 10 ml of water
  3. dry with materialdried (MgSO4)
  4. customthe solvent removed by rotary evaporation
  5. customThe residual material was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-89a58424e4b14357beb858368c4086ec
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05399702

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