2-Thiopheneacetic acid → HCID 20081438, 화합물

HRID 1609440

반응식

HRID 1609440 반응식
[CH3:1][C:2](C)([O-:4])C.[K+].[S:7]1C=CC=C1CC(O)=O.Br[CH:17]([CH:22]([CH3:24])[CH3:23])[C:18]([O:20][CH3:21])=[O:19]>CN(C)C=O.CCOCC>[C:2]([S:7][CH:17]([CH:22]([CH3:24])[CH3:23])[C:18]([O:20][CH3:21])=[O:19])(=[O:4])[CH3:1]

참가 물질

6

반응물 3

HCID 159702-Thiopheneacetic acidHCID 228837Methyl 2-bromo-3-methylbutanoateHCID 23665647Potassium tert-butoxide

생성물 1

HCID 20081438HCID 20081438, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6228Dimethylformamide용매

반응 조건

온도
10 °C

실험 절차

Potassium tert-butoxide (20.4 g) was added portionwise with stirring and cooling to thiolacetic acid (13.85 g) in dry dimethylformamide (150 ml). Stirring was continued for five minutes, then methyl 2-bromo-3-methylbutanoate (32.3 g) was added with ice-cooling (about 10° C. internal temperature). After stirring at room temperature overnight, the reaction mixture was diluted with ether (about 1 liter), washed with water (3 times), dried over magnesium sulfate and run down under vacuum. The title product was obtained as an orange oil, 29.2 g (93%).

후처리

  1. stirringStirring
  2. stirringAfter stirring at room temperature overnight
  3. washwashed with water (3 times)
  4. dry with materialdried over magnesium sulfate

출처 및 근거

ORD 기록
ord-2e2d480d1ef44d93bef10395f92d73ce
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05401710

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