2-Amino-4-nitrobenzaldehyde → 2,4-Diaminobenzaldehyde

HRID 1609473노트

반응식

HRID 1609473 반응식
[NH2:1][C:2]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]>[Pd]>[NH2:1][C:2]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

참가 물질

3

반응물 1

HCID 138911802-Amino-4-nitrobenzaldehyde

생성물 1

HCID 111477482,4-Diaminobenzaldehyde

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

In a manner similar to that described for 10-nitro-20(RS)- and 10-nitro-20(S)-camptothecin, a mixture of 2-amino-4-nitrobenzaldehyde is treated with the tricyclic ketone 11 yielding 11-nitro-20(RS)- or 11-nitro-20(S)-camptothecin which in turn is reduced to 11-amino compound camptothecin by palladium/carbon. Alternatively, the 11-amino-20(RS)- or 11-amino-20(S)-camptothecin is obtained by reaction of 2,4-diaminobenzaldehyde with ketone 11.

출처 및 근거

ORD 기록
ord-582e427aed984ac1a339686fa051ad35
출처 데이터셋
uspto-grants-1995_03
특허 번호
US05401747

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