참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Pyridinemethanamine | HCID 31018 | — |
| 반응물 | 6-Methoxyphthalide | HCID 330539 | — |
| 생성물 | 2-hydroxymethyl-5-methoxy-N-(3-pyridylmethyl)benzamide | HCID 20082005 | 91.8% |
반응 단계
A mixture of 919 mg of 6-methoxyisobenzofuran-1 (3H)-one and 1.82 g of 3-aminomethylpyridine was heated at 150° C. without solvent for 3 hours under stirring. After finishing the reaction, the mixture was chromatographed on a column of silica gel, eluting with ethyl acetate and then with tetrahydrofuran to give 1.40 g of the titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05401756 |
|---|
| 출처 데이터셋 | uspto-grants-1995_03 |
|---|
| ORD ID | ord-c962d1214f004a7bb3220bdf4e352a35 |
|---|
| 출처 메모 | uspto-grants-1995_03 |
|---|
