Thionyl Chloride → 2-Chloromethyl-3-methoxy-5-phenyl-pyrazine

HRID 1609834노트

반응식

HRID 1609834 반응식
[CH3:1][O:2][C:3]1[C:4]([CH2:15]O)=[N:5][CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:8]=1.O=S(Cl)[Cl:19]>C(Cl)Cl>[Cl:19][CH2:15][C:4]1[C:3]([O:2][CH3:1])=[N:8][C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][N:5]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 22260379HCID 22260379, 화합물

생성물 1

HCID 222603922-Chloromethyl-3-methoxy-5-phenyl-pyrazine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (3-methoxy-5-phenyl-pyrazin-2-yl)-methanol (60 mg, 0.28 mmol) in DCM (5 mL) is added SOCl2 (5 eq) at room temperature. The mixture is stirred at room temperature for an additional one hour. Solvent and volatile materials are removed in vacuo to dryness to give 65 mg of 2-chloromethyl-3-methoxy-5-phenyl-pyrazine as an oil.

후처리

  1. customSolvent and volatile materials are removed in vacuo to dryness

출처 및 근거

ORD 기록
ord-73644287c2e846038606a8c2b82dbad1
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06982268B2

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