HCID 68420482, 화합물 → HCID 68419822, 화합물

HRID 1610158노트

반응식

HRID 1610158 반응식
C(OC(=O)[NH:10][C:11]1[C:12]([O:49][CH3:50])=[C:13]2[C:17](=[CH:18][CH:19]=1)[N:16]([C:20]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[N:15]=[C:14]2[C:39]1[CH:48]=[CH:47][C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH:40]=1)C1C=CC=CC=1>C(OCC)(=O)C.CO.[C].[Pd]>[CH3:50][O:49][C:12]1[C:11]([NH2:10])=[CH:19][CH:18]=[C:17]2[C:13]=1[C:14]([C:39]1[CH:48]=[CH:47][C:46]3[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=3)[CH:40]=1)=[N:15][N:16]2[C:20]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

참가 물질

5

반응물 1

HCID 68420482HCID 68420482, 화합물

생성물 1

HCID 68419822HCID 68419822, 화합물수율 67.7%

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

466 mg of (4-methoxy-3-naphthalen-2-yl-1-trityl-1H-indazol-5-yl)-carbamic acid benzyl ester obtained in Production Example II-38-a was dissolved in 20 ml of a 1:1 solvent mixture of ethyl acetate and methanol. 300 mg of 10% palladium-carbon was added and the mixture was subjected to catalytic hydrogenation at room temperature and normal atmospheric pressure. The reaction mixture was filtered through Celite, and the solvent was removed, to give 252 mg of the title compound.

후처리

  1. customwas subjected to catalytic hydrogenation at room temperature
  2. filtrationThe reaction mixture was filtered through Celite
  3. customthe solvent was removed

출처 및 근거

ORD 기록
ord-b347b3c17933497da9f8c426da048ae1
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06982274B2

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