5-Methyl-2-(trifluoromethyl)-3-furancarboxylic acid → 2-Methyl-5-(trifluoromethyl)furan

HRID 1610327노트

반응식

HRID 1610327 반응식
[CH3:1][C:2]1[O:6][C:5]([C:7]([F:10])([F:9])[F:8])=[C:4](C(O)=O)[CH:3]=1>N1C2C(=CC=CC=2)C=CC=1.S([O-])([O-])(=O)=O.[Cu+].[Cu+]>[CH3:1][C:2]1[O:6][C:5]([C:7]([F:10])([F:9])[F:8])=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 27821835-Methyl-2-(trifluoromethyl)-3-furancarboxylic acid

생성물 1

HCID 109536882-Methyl-5-(trifluoromethyl)furan수율 54%

시약·촉매·용매 2

HCID 134737Sulfuric acid, copper(1+) salt (1:2)촉매HCID 7047Quinoline용매

실험 절차

To a solution of 5-methyl-2-(trifluoromethyl)-3-furancarboxylic acid (20 g, 103 mmol) in quinoline (36 ml) was added copper (I) sulfate (1 g, 6.3 mmol). While bubbling nitrogen, the mixture was immersed in an oil bath at 230° C. until gas generation ceased. The generated gas was collected and distilled again to give 2-methyl-5-(trifluoromethyl)furan (8.34 g, 54%).

후처리

  1. customWhile bubbling nitrogen
  2. customthe mixture was immersed in an oil bath at 230° C. until gas generation
  3. customThe generated gas was collected
  4. distillationdistilled again

출처 및 근거

ORD 기록
ord-1ad3a181e7444430b968eb54d685f291
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06982348B2

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