Benzyl 4-(pyridin-3-yloxy)benzoate → 4-(Pyridin-3-yloxy)benzoic acid

HRID 1610601

반응식

HRID 1610601 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][C:8]2[CH:23]=[CH:22][C:11]([C:12]([O:14]CC3C=CC=CC=3)=[O:13])=[CH:10][CH:9]=2)[CH:2]=1>C(O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([O:7][C:8]2[CH:23]=[CH:22][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=2)[CH:2]=1

참가 물질

4

반응물 1

HCID 22262109Benzyl 4-(pyridin-3-yloxy)benzoate

생성물 1

HCID 222616674-(Pyridin-3-yloxy)benzoic acid

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

To a solution of benzyl 4-(pyridin-3-yloxy)benzoate (18.0 g, 5.90 mmol) in ethanol (300 ml) was added 10% palladium/carbon (containing water by 50%, 2.0 g), and the mixture was stirred under a hydrogen stream at 80° C. overnight. The reaction solution was filtered with celite and the filtrate was concentrated. The residue was recrystallized from ethanol-hexane to give the objective substance (11.2 g, 88%).

후처리

  1. filtrationThe reaction solution was filtered with celite
  2. concentrationthe filtrate was concentrated
  3. customThe residue was recrystallized from ethanol-hexane
  4. customto give the objective substance (11.2 g, 88%)

출처 및 근거

ORD 기록
ord-1296fd1aaed04fa7848a8fa4f645c4b3
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06982348B2

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