Sulfuric Acid → HCID 22261682, 화합물
반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH2:13]=[C:14]([CH3:16])[CH3:15].S(=O)(=O)(O)O>ClCCl>[C:14]([O:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([O:7][CH2:8][CH3:9])=[O:6])([CH3:16])([CH3:15])[CH3:13]참가 물질
5
실험 절차
To a solution of ethyl 3-hydroxybenzoate (20 g, 0.13 mol) in dichloromethane (200 ml) were added isobutene (about 30 g) and conc. sulfuric acid (0.5 ml), and the mixture was left for 2 days. The reaction solution was washed with saturated aqueous sodium hydrogen carbonate solution, dried over anhydrous magnesium sulfate and evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane:ethyl acetate=10:1) to give the objective substance (17.3 g, 63%) as an oil.
후처리
- washThe reaction solution was washed with saturated aqueous sodium hydrogen carbonate solution
- dry with materialdried over anhydrous magnesium sulfate
- customevaporated under reduced pressure
- customThe residue was purified by silica gel chromatography (hexane:ethyl acetate=10:1)
- customto give the objective substance (17.3 g, 63%) as an oil
출처 및 근거
- ORD 기록
- ord-d44bede4e3ee4c1785b0220770d19feb
- 출처 데이터셋
- uspto-grants-2006_01
- 특허 번호
- US06982348B2
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