Water → (3-TERT-BUTOXY-PHENYL)-METHANOL
반응식
[C:1]([O:5][C:6]1[CH:7]=[C:8]([CH:14]=[CH:15][CH:16]=1)[C:9](OCC)=[O:10])([CH3:4])([CH3:3])[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[C:1]([O:5][C:6]1[CH:7]=[C:8]([CH:14]=[CH:15][CH:16]=1)[CH2:9][OH:10])([CH3:4])([CH3:2])[CH3:3]참가 물질
5
실험 절차
To a solution of ethyl 3-tert-butyloxybenzoate (16.7 g, 80 mmol) in tetrahydrofuran (100 ml) was added lithium aluminum hydride (4.55 g, 120 mmol) by small portions under ice-cooling. The mixture was stirred at room temperature for 1 hr. and water (10 ml) was added under ice-cooling to allow decomposition. Insoluble material was filtered off and the solvent was evaporated under reduced pressure. The residue was purified by silica gel chromatography (hexane:ethyl acetate=3:1-2:1) to give the objective substance (12.8 g, 88%) as an oil.
후처리
- temperaturecooling
- temperaturecooling
- filtrationInsoluble material was filtered off
- customthe solvent was evaporated under reduced pressure
- customThe residue was purified by silica gel chromatography (hexane:ethyl acetate=3:1-2:1)
- customto give the objective substance (12.8 g, 88%) as an oil
출처 및 근거
- ORD 기록
- ord-b1dd10a15552419eb20ef2a9886c4f9e
- 출처 데이터셋
- uspto-grants-2006_01
- 특허 번호
- US06982348B2
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