2-Fluorobenzoyl chloride → 2-[1-(2-Fluorobenzoyl)-4,5-dimethyl-1H-imidazol-2-yl]-1-(2-fluorophenyl)ethenyl 2-fluorobenzoate

HRID 1610825노트

반응식

HRID 1610825 반응식
[CH3:1][C:2]1[NH:3][C:4]([CH3:8])=[C:5]([CH3:7])[N:6]=1.[F:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](Cl)=[O:13]>C(#N)C>[F:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([O:13][C:12]([C:11]1[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=1[F:9])=[CH:1][C:2]1[N:3]([C:12](=[O:13])[C:11]2[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=2[F:9])[C:4]([CH3:8])=[C:5]([CH3:7])[N:6]=1)=[O:13]

참가 물질

4

반응물 2

HCID 98082-Fluorobenzoyl chlorideHCID 699762,4,5-Trimethylimidazole

생성물 1

HCID 695894172-[1-(2-Fluorobenzoyl)-4,5-dimethyl-1H-imidazol-2-yl]-1-(2-fluorophenyl)ethenyl 2-fluorobenzoate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
0 °C

실험 절차

3.00 g (27.23 mmol) 2,4,5-trimethyl-1H-imidazol and 9.37 g (92.59 mmol) TEA are dissolved in 50 ml acetonitrile and cooled to 0° C. 14.25 g (89.87 mmol) 2-fluoro-benzoylchloride are added dropwise and the mixture is stirred 2 h at RT and let stand overnight. The solvent is removed under vacuum, the residue is dissolved in toluene and washed twice with water. The organic phase is filtered through Tonsil (K60) and concentrated under vacuum. The product is used without further purification.

후처리

  1. waitlet stand overnight
  2. customThe solvent is removed under vacuum
  3. dissolutionthe residue is dissolved in toluene
  4. washwashed twice with water
  5. filtrationThe organic phase is filtered through Tonsil (K60)
  6. concentrationconcentrated under vacuum
  7. customThe product is used without further purification

출처 및 근거

ORD 기록
ord-f1169e002d6341e795cbecafdb26e692
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06984646B2

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