Potassium Hydroxide → HCID 22258169, 화합물

HRID 1610879노트

반응식

HRID 1610879 반응식
[Br:1][C:2]1[N:6]2[C:7](Cl)=[CH:8][CH:9]=[C:10]([C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:12])[C:5]2=[N:4][CH:3]=1.[OH-:20].[K+]>C(O)C>[C:11]([C:10]1[CH:9]=[CH:8][C:7](=[O:20])[N:6]2[C:2]([Br:1])=[CH:3][NH:4][C:5]=12)(=[O:12])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 22258287HCID 22258287, 화합물

생성물 1

HCID 22258169HCID 22258169, 화합물수율 4.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

40 mg (0.12 mmol) of 3-bromo-5chloroimidazo[1,2-a]pyridin-8-yl)(phenyl)methanone (example L) are dissolved in 5 ml of potassium hydroxide—solution (10% in water) and 5 ml of ethanol. The mixture is stirred for 24 h at rt. The solvent is evaporated under vacuum and water is added to the crude. The solution is extracted for with ethyl acetate. The collected organic phases are reextracted with brine solution and dried over sodium sulfate. The solvent is evaporated under vacuum and the crude is purified over preparative HPLC (RP18-Column, eluent: acetonitrilewater-gradient) to yield 1.6 mg (4.2% of th.) 8-Benzoyl-3-bromoimidazo[1,2-a]pyridin-5(1H)-one.

후처리

  1. customThe solvent is evaporated under vacuum and water
  2. additionis added to the crude
  3. extractionThe solution is extracted for with ethyl acetate
  4. dry with materialdried over sodium sulfate
  5. customThe solvent is evaporated under vacuum
  6. customthe crude is purified over preparative HPLC (RP18-Column, eluent: acetonitrilewater-gradient)

출처 및 근거

ORD 기록
ord-260ac36685df41e3966a86263b03f220
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06984646B2

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