Ethanol → Ethyl [1-(3,4-dichlorobenzyl)piperidin-4-yl]acetate

HRID 1610907노트

반응식

HRID 1610907 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[CH2:5][N:6]1[CH2:11][CH2:10][C:9](=[CH:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:8][CH2:7]1.C(O)C>O1CCCC1.[Pt]=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[Cl:21])[CH2:5][N:6]1[CH2:7][CH2:8][CH:9]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:10][CH2:11]1

참가 물질

5

반응물 2

HCID 702EthanolHCID 18351421HCID 18351421, 화합물

생성물 1

HCID 10758769Ethyl [1-(3,4-dichlorobenzyl)piperidin-4-yl]acetate수율 99.5%

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl [1-(3,4-dichlorobenzyl)piperidin-4-ylidene]acetate (3.9 g, 11.9 mmol) dissolved in tetrahydrofuran (25 ml) and ethanol (25 ml) was subjected to hydrogenation over platinum oxide (0.1 g) at ambient temperature and atmospheric pressure. The reaction mixture was filtered through a celite pad and concentrated in vacuo to give ethyl [1-(3,4-dichlorobenzyl)piperidin-4-yl]acetate (3.91 g) as a semi-solid.

후처리

  1. filtrationThe reaction mixture was filtered through a celite pad
  2. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-d6a9b6a674a246d599c57c0f981895dd
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06984637B2

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