Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → HCID 9857126, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 1,3-Dichloroacetone | HCID 10793 | — |
| 반응물 | 4-(Trifluoromethyl)cinnamamide | HCID 5709014 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | HCID 9857126 | HCID 9857126 | 63.1% |
반응 단계
A mixture of (E)-3-(4-trifluoromethylphenyl)-2-propenamide (17.9 g) and 1,3-dichloroacetone (14.8 g) in toluene (83 ml) was refluxed for 9 hours by use of Dean-Stark apparatus. After cooling, the reaction mixture was combined with water, extracted with ethyl acetate, washed with saturated brine, and dried over magnesium sulfate, then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane:ethyl acetate=6:1 to 5:1) to give the titled compound (15.1 g) as colorless needle crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06984653B2 |
| 출처 데이터셋 | uspto-grants-2006_01 |
| ORD ID | ord-f5e6a1b5218143e3a243ec9ba534379d |
| 출처 메모 | uspto-grants-2006_01 |