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Water → HCID 22259357, 화합물

HRID 1610975
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HRID 1610975 반응식
[H-].[Al+3].[Li+].[H-].[H-].[H-].[F:7][C:8]([F:45])([F:44])[C:9]1[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[C:17]2[O:18][CH:19]=[C:20]([CH2:22][O:23][C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][CH2:32][CH2:33][N:34]4[CH:38]=[C:37]([C:39](OCC)=[O:40])[N:36]=[N:35]4)=[CH:26][CH:25]=3)[N:21]=2)=[CH:11][CH:10]=1.C(OCC)C.O>C1COCC1>[F:45][C:8]([F:7])([F:44])[C:9]1[CH:10]=[CH:11][C:12](/[CH:15]=[CH:16]/[C:17]2[O:18][CH:19]=[C:20]([CH2:22][O:23][C:24]3[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][CH2:32][CH2:33][N:34]4[CH:38]=[C:37]([CH2:39][OH:40])[N:36]=[N:35]4)=[CH:26][CH:25]=3)[N:21]=2)=[CH:13][CH:14]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 3283Diethyl EtherHCID 21226445Aluminium lithium hydrideHCID 22259358HCID 22259358, 화합물

생성물 1

HCID 22259357HCID 22259357, 화합물수율 94.3%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Lithium aluminium hydride (35 mg) was added to a solution of ethyl 1-(4-{4-[(2-{(E)-2-[4-(trifluoromethyl)phenyl]ethenyl}-1,3-oxazol-4-yl)methoxy]phenyl}butyl)-1H-1,2,3-triazole-4-carboxylate (500 mg) in THF (10 ml) at 0° C., and the mixture was stirred for 30 min. After the reaction was completed, the reaction mixture was combined with diethyl ether and water and filtered with Celite. The solvent was evaporated under reduced pressure, and the residue was recrystallized from ethyl acetate-hexane to give the titled compound (435 mg) as a colorless crystal powder.

후처리

  1. filtrationfiltered with Celite
  2. customThe solvent was evaporated under reduced pressure
  3. customthe residue was recrystallized from ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-f2a95e43965f41428ff31e75968fc332
출처 데이터셋
uspto-grants-2006_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06984653B2

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