3-(1-Naphthalenyl)-2-propenoic acid → 1-Naphthalenepropionic acid

HRID 1611009노트

반응식

HRID 1611009 반응식
[C:1]1([CH:11]=[CH:12][C:13]([OH:15])=[O:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1>[Pd].O1CCCC1>[C:1]1([CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 1

HCID 983073-(1-Naphthalenyl)-2-propenoic acid

생성물 1

HCID 952541-Naphthalenepropionic acid수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

10% Palladium on carbon (1.00 g) was added to a suspension of 3-(1-naphthyl)acrylic acid (50.0 g) in tetrahydrofuran (500 ml). The mixture was hydrogenated at 6 atmospheres for 18 hours then filtered through a kieselguhr pad washing with ethyl acetate (3×10 ml). The filtrate was evaporated under reduced pressure to give the subtitle compound (50.0 g) as a solid.

후처리

  1. filtrationthen filtered through a kieselguhr pad
  2. washwashing with ethyl acetate (3×10 ml)
  3. customThe filtrate was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-5673ec474f694bc49623cf8b3c0713f0
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06984644B2

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