Ethanol → 2-Butyl-5-nitrobenzofuran

HRID 1611058

반응식

HRID 1611058 반응식
[CH2:1]([CH:5]1[CH:9](O)[C:8]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:7]=2[O:6]1)[CH2:2][CH2:3][CH3:4].C(O)C.S(=O)(=O)(O)O>O>[CH2:1]([C:5]1[O:6][C:7]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][C:8]=2[CH:9]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 103317102-Butyl-5-nitro-2,3-dihydrobenzofuran-3-ol

생성물 1

HCID 98373582-Butyl-5-nitrobenzofuran

시약·촉매·용매 1

HCID 962Water용매

실험 절차

300 mg of 2-(n-butyl)-5-nitro-2,3-dihydrobenzofuran-3-ol were introduced into ethanol in a 50 ml flask, and 1 ml of concentrated sulphuric acid was added. The mixture was then heated to reflux for 4 hours. After cooling, 10 ml of water were added, the ethanol was distilled off, and the mixture was extracted with dichloromethane. Washing of the organic phase with sodium bicarbonate solution, drying over sodium sulphate and removal of the solvent in vacuo resulted in 220 mg (80% of theory) of 2-(n-butyl)-5-nitrobenzofuran as yellow oil.

후처리

  1. temperatureThe mixture was then heated
  2. temperatureto reflux for 4 hours
  3. temperatureAfter cooling
  4. distillationthe ethanol was distilled off
  5. extractionthe mixture was extracted with dichloromethane
  6. washWashing of the organic phase with sodium bicarbonate solution
  7. dry with materialdrying over sodium sulphate and removal of the solvent in vacuo
  8. customresulted in 220 mg (80% of theory) of 2-(n-butyl)-5-nitrobenzofuran as yellow oil

출처 및 근거

ORD 기록
ord-62778510f2cb4ef2bc3009427bc48621
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06984741B2

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