(2S)-2-[[4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro-5-(trifluoromethyl) [1,1'-biphenyl]-2-yl]oxy]-propanoic acid → (2S)-2-[[5-chloro-4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

HRID 16112

반응식

HRID 16112 반응식
[CH3:1][C:2]([NH:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[C:18](C(F)(F)F)[CH:17]=[CH:16][C:15]=2[O:24][C@@H:25]([CH3:29])[C:26]([OH:28])=[O:27])=[CH:10][C:9]=1[F:30])=[O:7])([CH3:4])[CH3:3].B(C1C=C([Cl:46])C=CC=1O[C@@H](C)C(O)=O)(O)O>>[Cl:46][C:18]1[CH:17]=[CH:16][C:15]([O:24][C@@H:25]([CH3:29])[C:26]([OH:28])=[O:27])=[C:14]([C:11]2[CH:12]=[CH:13][C:8]([C:6]([NH:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:7])=[C:9]([F:30])[CH:10]=2)[CH:19]=1

참가 물질

3

반응물 2

HCID 11539174(2S)-2-[[4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro-5-(trifluoromethyl) [1,1'-biphenyl]-2-yl]oxy]-propanoic acidHCID 67277298(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid

생성물 1

HCID 11538441(2S)-2-[[5-chloro-4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

실험 절차

The title compound was prepared using the product of example 33 step a) and the product of example 28 step c) by the method of example 32 step b).

출처 및 근거

ORD 기록
ord-dff6b5a0db1547c19bd0363b932ca948
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737135B2

연결된 노트

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