2-(Bromomethyl)-1,4-difluorobenzene → HCID 15957751, 화합물

반응식

[CH2:1]([C:3]1[C:4](=[O:20])[NH:5][C:6](=[O:19])[NH:7][C:8]=1[C:9](=[O:18])[C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[F:21][C:22]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:23]=1[CH2:24]Br>>[F:21][C:22]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][C:23]=1[CH2:24][N:7]1[C:8]([C:9](=[O:18])[C:10]2[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=2)=[C:3]([CH2:1][CH3:2])[C:4](=[O:20])[NH:5][C:6]1=[O:19]

참가 물질

반응물 2

HCID 5228302-(Bromomethyl)-1,4-difluorobenzene

HCID 222565796-(3,5-dimethylbenzoyl)-5-ethylpyrimidine-2,4(1H,3H)-dione

생성물 1

HCID 15957751HCID 15957751, 화합물수율 53.7%

실험 절차

5-Ethyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 2,5-difluorobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (214 mg, yield: 53.7%).

출처 및 근거

ORD 기록: ord-d1532a9c6baa476a9520df62c32a4815
출처 데이터셋: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06987114B1

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