Sulfuric Acid → 2-Phenoxyethanol Ether

HRID 1611473

반응식

HRID 1611473 반응식
[O:1]([CH2:8][CH2:9][OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+].C1OC1C.C1OC1.C1OC1C.C1OC1.S(=O)(=O)(O)O>>[O:1]([CH2:8][CH2:9][OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:3][CH2:2][O:1][CH2:8][CH3:9]

참가 물질

7

반응물 6

HCID 1118Sulfuric AcidHCID 6354Ethylene OxideHCID 6378Propylene OxideHCID 14797Potassium HydroxideHCID 24751Crl-8131HCID 31236Phenoxyethanol

생성물 1

HCID 694146262-Phenoxyethanol Ether

반응 조건

온도
110 °C

실험 절차

To a clean, dry stirred tank pressure vessel with nitrogen inlet is charged 1553.93 g (11.25 moles) of 2-Phenoxyethanol and a catalytic amount (16.67 g) of 45% KOH. The vessel is purged with nitrogen and heated to 110° C. Vacuum is applied for 1 hour to remove trace amounts of water and the temperature is raised to 150° C. A mixture of 1919.03 g (33.04 moles) of Propylene Oxide and 873.28 g (19.82 moles) of Ethylene Oxide is added at a constant rate to keep the pressure below 50 psig. After all Propylene Oxide/Ethylene Oxide is added, the reaction mixture is allowed to react for an additional hour after which the temperature is lowered to 110° C. and vacuum is applied for one hour. The reaction mixture is cooled to 65° C. and the catalyst is neutralized with an equivalent molar amount of 25% Sulfuric Acid.

후처리

  1. customTo a clean, dry
  2. customThe vessel is purged with nitrogen
  3. customto remove trace amounts of water
  4. temperaturethe temperature is raised to 150° C
  5. additionis added at a constant rate
  6. customto react for an additional hour after which the temperature
  7. customis lowered to 110° C.
  8. waitvacuum is applied for one hour
  9. temperatureThe reaction mixture is cooled to 65° C.

출처 및 근거

ORD 기록
ord-87481dc0e4e24291accb98ed248b9f0c
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06987195B2

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