Ammonia → 8-(4-(3-Anilinophenoxy)-1-methylbutoxy)quinolin-2-amine

HRID 1611689

반응식

[NH:1]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:15][C:16]1[CH:17]=[C:18]([CH:23]=[CH:24][CH:25]=1)[C:19](OC)=O.[NH3:26]>>[NH:1]([C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=1)[O:14][CH2:12][CH2:13][CH2:8][CH:9]([CH3:10])[O:15][C:16]1[CH:25]=[CH:24][CH:23]=[C:18]2[C:17]=1[N:26]=[C:2]([NH2:1])[CH:3]=[CH:19]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

반응물 3

HCID 222Ammonia

HCID 75463-Hydroxy-N-phenylaniline

HCID 88068Methyl 3-Hydroxybenzoate

생성물 1

HCID 100703478-(4-(3-Anilinophenoxy)-1-methylbutoxy)quinolin-2-amine

실험 절차

The title compound was prepared according to the procedure described in Example 92 substituting 3-anilinophenol for methyl 3-hydroxybenzoate. 1H NMR (500 MHz, CDCl3) δ ppm 7.91 (d, 1H), 7.26 (m, 3H), 7.16 (m, 1H), 7.12 (m, 1H), 7.07 (m, 3H), 6.94 (d, 1H), 6.91 (m, 1H), 6.60 (m, 1H), 6.52 (t, 1H), 6.37 (m, 1H), 4.69 (m, 1H), 4.03 (m, 1H), 3.96 (m, 1H), 2.18 (m, 1H), 1.96 (m, 3H), 1.46 (d, 3H); MS (DCI/NH3) m/z 414 [M+H]+.

출처 및 근거

ORD 기록: ord-eecabcd3960d48c794ad8350cd4139cf
출처 데이터셋: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06989392B2

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