3-Cyclopropyl-6-methylpiperazine-2,5-dione → 3-Cyclopropyl-6-ethylpiperazine-2,5-dione

반응식

C1(C2NC(=O)C(C)NC2=O)CC1.Cl.[NH2:14][CH:15]([CH2:27][CH3:28])[C:16]([NH:18][CH:19]([CH:24]1[CH2:26][CH2:25]1)[C:20](OC)=[O:21])=[O:17]>>[CH:24]1([CH:19]2[NH:18][C:16](=[O:17])[CH:15]([CH2:27][CH3:28])[NH:14][C:20]2=[O:21])[CH2:26][CH2:25]1

참가 물질

반응물 2

HCID 221473683-Cyclopropyl-6-methylpiperazine-2,5-dione

HCID 86588881Methyl[(2-aminobutanoyl)amino](cyclopropyl)acetate hydrochloride

생성물 1

HCID 221475383-Cyclopropyl-6-ethylpiperazine-2,5-dione

실험 절차

Following the procedure for the preparation of 3-cyclopropyl-6-methylpiperazine-2,5-dione but substituting methyl [(2-aminobutanoyl)amino](cyclopropyl)acetate hydrochloride and making non-critical variations provided the title compound as a solid: 1H NMR (DMSO-d6) δ 0.29-0.48, 0.79-1.20, 1.69, 3.20, 3.93, 8.05.

출처 및 근거

ORD 기록: ord-99346f416b5248d5a3f7dfd92099495d
출처 데이터셋: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06992087B2

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