1,8-Diazabicyclo(5.4.0)undec-7-ene → Dimethyl 5-(2-oxopyrrolidin-1-yl)isophthalate

HRID 1612471노트

반응식

HRID 1612471 반응식
[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:13]=[C:12]([NH:14][C:15](=[O:20])[CH2:16][CH2:17][CH2:18]Br)[CH:11]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[CH:5]=1.C1CCN2C(=NCCC2)CC1>>[CH3:1][O:2][C:3](=[O:21])[C:4]1[CH:13]=[C:12]([N:14]2[CH2:18][CH2:17][CH2:16][C:15]2=[O:20])[CH:11]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[CH:5]=1

참가 물질

3

반응물 2

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 695897185-(4-Bromo-butanoylamino)-isophthalic Acid Dimethyl Ester

생성물 1

HCID 57513093Dimethyl 5-(2-oxopyrrolidin-1-yl)isophthalate수율 35%

실험 절차

5-(4-Bromo-butanoylamino)-isophthalic acid dimethyl ester (D61) was treated with DBU as described in D57 to afford D62 as a white solid (35%).

출처 및 근거

ORD 기록
ord-f8ccfd99d66a47a7986c84bde8e1acb8
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06992103B2

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