Aldono-1,5-lactone → {2-[2-(2,3,4,5,6-Pentahydroxyhexanoylamino)ethoxy]ethoxy}acetic acid

HRID 1612524

반응식

HRID 1612524 반응식
C(=O)([O-])[O-].[Na+].[Na+].[NH2:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][O:13][CH2:14][C:15]([OH:17])=[O:16].[OH:18][CH:19]1[CH:24]([OH:25])[CH:23]([OH:26])[CH:22]([CH2:27][OH:28])[O:21][C:20]1=[O:29]>CO>[OH:21][CH:22]([CH:23]([OH:26])[CH:24]([OH:25])[CH:19]([OH:18])[CH2:20][OH:29])[C:27]([NH:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][O:13][CH2:14][C:15]([OH:17])=[O:16])=[O:28]

참가 물질

5

반응물 3

HCID 736Aldono-1,5-lactoneHCID 10340Sodium CarbonateHCID 362706(2-(2-Aminoethoxy)ethoxy)acetic acid

생성물 1

HCID 22252087{2-[2-(2,3,4,5,6-Pentahydroxyhexanoylamino)ethoxy]ethoxy}acetic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

172 mg of sodium carbonate are added to a solution of 450 mg of [2-(2-aminoethoxy)ethoxy]acetic acid and 318 mg of 3,4,5-trihydroxy-6-hydroxymethyltetrahydropyran-2-one in 10 ml of methanol, and the mixture is stirred at room temperature until the reaction has gone to completion. The reaction solution is filtered and concentrated. The residue is taken up in water and acetonitrile (1/1), resulting in the formation of 2 phases. The aqueous phase is concentrated and contains 20:

후처리

  1. filtrationThe reaction solution is filtered
  2. concentrationconcentrated
  3. customacetonitrile (1/1), resulting in the formation of 2 phases
  4. concentrationThe aqueous phase is concentrated

출처 및 근거

ORD 기록
ord-05bb12cd814a457bae2c863d522dd03b
출처 데이터셋
uspto-grants-2006_01
특허 번호
US06992067B2

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