4-Hydroxybenzoic Acid → 3-Methylpentyl p-hydroxybenzoate

HRID 1612584

반응식

HRID 1612584 반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.[CH3:11][C@@H:12]([CH2:16][CH3:17])[CH2:13][CH2:14]O.S(=O)(=O)(O)O>C1(C)C=CC=CC=1>[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH2:14][CH2:13][CH:12]([CH3:11])[CH2:16][CH3:17])=[O:7])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 1354-Hydroxybenzoic AcidHCID 1118Sulfuric AcidHCID 641003(S)-(+)-3-Methyl-1-pentanol

생성물 1

HCID 190183233-Methylpentyl p-hydroxybenzoate수율 80.7%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

13.7 g of p-hydroxybenzoic acid and 11.4 g of (S)-(+)-3-methyl-1-pentanol were refluxed for 10 hours in toluene in the presence of sulfuric acid, while removing out the generated water from the reaction system. Subsequently, the reaction solution was washed with water to remove the sulfuric acid out. The reaction solution was then dried, concentrated, and purified by column chromatography, to obtain 17.8 g of the objective ester compound (liquid state at room temperature ([α]d23 =+7.8° (CHCl3)). (Yield: 80%)

후처리

  1. customwhile removing out the generated water from the reaction system
  2. washSubsequently, the reaction solution was washed with water
  3. customto remove the sulfuric acid out
  4. customThe reaction solution was then dried
  5. concentrationconcentrated
  6. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-6bc979b37a944b2d817462a48611bb6f
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05190686

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