Benzyl Bromide → HCID 11044573, 화합물

HRID 1612880노트

반응식

[C:1]([CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].[CH2:9](Br)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH2:9]([C:3]([C:1]#[N:2])([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

반응물 2

HCID 7498Benzyl Bromide

HCID 7764Ethyl cyanoacetate

생성물 1

HCID 11044573HCID 11044573, 화합물수율 80%

실험 절차

Ethyl cyanoacetate (15.0 g, 0.133 mol) was dialkylated with benzyl bromide employing 1,8-diazabicyclo[5.4.0]undecene-7 as described by: Ono, N.; Yoshimura, T.; Tanikaga, R.; Kaji, A. Chem. Lett. 1977, 871-872. The obtained ethyl 2-benzyl-2-cyano-3-phenylpropionate (80% yield) was identical with the material described in Example 88. The ester was saponified to the corresponding carboxylic acid as previously described in Example 88. The title peptide was prepared under standard solid phase peptide conditions as examplified in Examples 1 and 2.

출처 및 근거

ORD 기록: ord-55518e9ba424475791aa380530e83fbc
출처 데이터셋: uspto-grants-1993_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05190922

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