Potassium Hydroxide → HCID 12740769, 화합물

HRID 1612881노트

반응식

HRID 1612881 반응식
[CH2:1]([C:8]([C:21]#[N:22])([CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]([O:11]CC)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[K+]>O.C(O)C.O>[CH2:14]([C:8]([C:21]#[N:22])([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:9]([OH:11])=[O:10])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 11044573HCID 11044573, 화합물

생성물 1

HCID 12740769HCID 12740769, 화합물수율 100%

시약·촉매·용매 2

HCID 962Water용매HCID 19096565Water ethanol용매

실험 절차

Ethyl 2-benzyl-2-cyano-3-phenylpropionate (3.20 g, 11 mmol) was saponified at room temperature overnight with potassium hydroxide (6.17 g, 0.11 mol) in 10% water/ethanol. The mixture was diluted with water (200 mL) and extracted with hexane (2×50 mL). The aqueous layer was acidified with 1M phosphoric acid and extracted with methylene chloride (4×100 mL). The combined organic extracts were dried over magnesium sulfate and freed of solvent to afford 2-benzyl-2-cyano-3-phenylpropionic acid (2.94 g, 11 mmol) as a colorless solid: 1H NMR (CDCl3, 300 MHz) δ 7.34 (br s, 10 H), 3.24 (dd, J=13.5, 57 Hz); mass spectrum m/e 283 (M+NH4+).

후처리

  1. extractionextracted with hexane (2×50 mL)
  2. extractionextracted with methylene chloride (4×100 mL)
  3. dry with materialThe combined organic extracts were dried over magnesium sulfate

출처 및 근거

ORD 기록
ord-1a0424da5b634df880cda4efe63ecfd9
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05190922

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