4-Benzyl-2-(methoxymethyl)morpholine → 2-(Methoxymethyl)morpholine

HRID 1612955노트

반응식

HRID 1612955 반응식
C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][O:15][CH3:16])[CH2:9]1)C1C=CC=CC=1>CO.[C].[Pd]>[CH3:16][O:15][CH2:14][CH:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1

참가 물질

4

반응물 1

HCID 103534614-Benzyl-2-(methoxymethyl)morpholine

생성물 1

HCID 149332022-(Methoxymethyl)morpholine수율 86.9%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매2회HCID 887Methanol용매

반응 조건

온도
100 °C

실험 절차

N-Benzyl-2-methoxymethylmorpholine (412.3 g) is dissolved in methanol (2 liters), and thereto is added 10% palladium-carbon (33 g), and the mixture is stirred under hydrogen pressure of 9 kg/cm2 at 100° C. After completion of the reaction, palladium-carbon is filtered off, and the solvent is distilled off under atmospheric pressure to give a pale yellow oily substance. The oily substance is distilled under reduced pressure to give the title compound (212.3 g) as colorless liquid.

후처리

  1. filtrationis filtered off
  2. distillationthe solvent is distilled off under atmospheric pressure
  3. customto give a pale yellow oily substance
  4. distillationThe oily substance is distilled under reduced pressure

출처 및 근거

ORD 기록
ord-dcfe83be3ce146faa2c05a842c1d20fb
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05191079

반응 노트

불러오는 중…