Ethyl bromoacetate → HCID 54112137, 화합물

HRID 1612974노트

반응식

HRID 1612974 반응식
[OH:1][C:2]1[CH:15]=[C:14]2[C:9]([CH2:10][CH2:11][CH2:12][CH2:13]2)=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][C:7]2=[O:16].Br[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20].C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[CH2:13]1[C:14]2[C:9](=[C:8]3[C:3](=[C:2]([O:1][CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH:15]=2)[CH2:4][CH2:5][CH2:6][C:7]3=[O:16])[CH2:10][CH2:11][CH2:12]1

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 19782189HCID 19782189, 화합물

생성물 1

HCID 54112137HCID 54112137, 화합물

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

40.44 g (0.19 mol) of the compound from Example 6 is heated to reflux with 38.64 g (0.23 mol) of ethyl bromoacetate and 31.97 g (0.23 mol) of potassium carbonate in 190 ml of butanone for 5 h. After cooling, the precipitate is filtered off and washed well with acetone and the solution is evaporated. The residue is taken up in 100 ml of CH2Cl2, shaken 3 times with 50 ml of 10% strength NaOH solution each time, dried over Na2SO4 and evaporated. The residue is dried in a high vacuum.

후처리

  1. temperatureAfter cooling
  2. filtrationthe precipitate is filtered off
  3. washwashed well with acetone
  4. customthe solution is evaporated
  5. dry with materialdried over Na2SO4
  6. customevaporated
  7. customThe residue is dried in a high vacuum

출처 및 근거

ORD 기록
ord-0873e14f4dd64666bc2bc8d8ef31ff26
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05191092

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