Sodium Carbonate → 3-Bromo-5-cyano-4'-t-butyldiphenylsilyloxvmethylbiphenyl

HRID 1613150노트

반응식

HRID 1613150 반응식
[O:1]([CH2:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1)[Si:2]([C:15]([CH3:18])([CH3:17])[CH3:16])([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Br:29][C:30]1[CH:31]=[C:32]([CH:35]=[C:36](Br)[CH:37]=1)[C:33]#[N:34].C(=O)([O-])[O-].[Na+].[Na+]>C1(C)C=CC=CC=1.C(O)C>[Br:29][C:30]1[CH:37]=[C:36]([C:23]2[CH:24]=[CH:25][C:20]([CH2:19][O:1][Si:2]([C:15]([CH3:18])([CH3:17])[CH3:16])([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:3]3[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=3)=[CH:21][CH:22]=2)[CH:35]=[C:32]([C:33]#[N:34])[CH:31]=1

참가 물질

6

반응물 3

HCID 10340Sodium CarbonateHCID 27976903,5-DibromobenzonitrileHCID 15224568(4-(((tert-Butyldiphenylsilyl)oxy)methyl)phenyl)boronic acid

생성물 1

HCID 194324363-Bromo-5-cyano-4'-t-butyldiphenylsilyloxvmethylbiphenyl

시약·촉매·용매 2

HCID 702Ethanol용매HCID 1140Toluene용매

반응 조건

온도
80 °C

실험 절차

A mixture of 1.49 g (3.83 mmoles) of boronic acid derivative from Example 4, 2.0 g (7.67 mmoles) of 3,5-dibromobenzonitrile, and 133 mg (0.1 mmoles) of tetrakistriphenylphosphine in 16 mL toluene and 3.4 mL 95% ethanol with 3.47 mL (6.97 mmoles) of 2 N sodium carbonate was stirred vigorously at 80° C. under nitrogen for 3.5 hours.

출처 및 근거

ORD 기록
ord-c5c790c91d80442d82ab6c48d9a49b40
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05192758

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