Potassium Carbonate → 1-(2-Benzothiazolyl)-4-piperidinemethanol

HRID 1613206노트

반응식

HRID 1613206 반응식
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.Cl[C:10]1[S:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[S:11]1[C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=[C:10]1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][OH:1])[CH2:4][CH2:5]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 119872-ChlorobenzothiazoleHCID 4207714-Piperidinemethanol

생성물 1

HCID 197495981-(2-Benzothiazolyl)-4-piperidinemethanol

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

30 g of 4-hydroxymethylpiperidine, 44 g of 2-chlorobenzothiazole and 72 g of potassium carbonate are reacted in 600 ml of acetonitrile under reflux overnight. After filtration and evaporation of the solvent, the residue is taken up in 200 ml of ethyl acetate and extracted with 1 N hydrochloric acid. The aqueous phase is made alkaline with caustic soda and extracted with dichloromethane. The expected product is obtained by drying and evaporation.

후처리

  1. temperatureunder reflux overnight
  2. filtrationAfter filtration and evaporation of the solvent
  3. extractionextracted with 1 N hydrochloric acid
  4. extractionextracted with dichloromethane

출처 및 근거

ORD 기록
ord-7f922d2d96cf4bff91317eda8dd11e04
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05192775

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