Thioacetamide → HCID 19775571, 화합물

HRID 1613230노트

반응식

HRID 1613230 반응식
Cl[CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1)[C:3](=O)[CH3:4].[C:16]([NH2:19])(=[S:18])[CH3:17]>C(O)C.CCCCC>[CH3:17][C:16]1[S:18][C:2]([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=2)=[C:3]([CH3:4])[N:19]=1

참가 물질

5

반응물 2

HCID 2723949ThioacetamideHCID 19775550HCID 19775550, 화합물

생성물 1

HCID 19775571HCID 19775571, 화합물수율 68.3%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8003Pentane용매

실험 절차

4.7 g of 3-chloro-4-(4-nitrophenyl)butan-2-one and 2.4 g of thioacetamide are dissolved in 60 ml of ethanol and refluxed for 12 hours. The reaction medium is concentrated, the residue is taken up in water and the solution is rendered basic with sodium carbonate and extracted with chloroform. After concentration of the organic phase, the solid obtained is taken up in hot pentane to give 3.5 g of 2,4-dimethyl-5-(4-nitrobenzyl)thiazole in the form of yellow crystals melting at 66° C.

후처리

  1. temperaturerefluxed for 12 hours
  2. concentrationThe reaction medium is concentrated
  3. extractionextracted with chloroform
  4. customAfter concentration of the organic phase, the solid obtained

출처 및 근거

ORD 기록
ord-3a57211ae5f14641b84657733032337c
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05192781

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