Sodium Bicarbonate → N-(4-diethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide

HRID 1613287노트

반응식

HRID 1613287 반응식
Cl.[CH2:2]([N:4]([CH2:26][CH3:27])[CH2:5][C:6]#[C:7][CH2:8][NH:9][C:10](=[O:25])[C:11](Cl)([CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:3].C(=O)(O)[O-:29].[Na+]>O>[CH2:2]([N:4]([CH2:26][CH3:27])[CH2:5][C:6]#[C:7][CH2:8][NH:9][C:10](=[O:25])[C:11]([CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)([OH:29])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH3:3]

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 19775490N-(4-diethylamino-2-butynyl)-2-chloro-2-cyclohexyl-2-phenylacetamide hydrochloride

생성물 1

HCID 14931302N-(4-diethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

N-(4-Diethylamino-2-butynyl)-2-chloro-2-cyclohexyl-2-phenylacetamide hydrochloride (100 mg) was dissolved in water (1 ml) and the solution was refluxed for 20 minutes. After being cooled, the solution was made alkaline (pH 10) with saturated sodium bicarbonate aqueous solution and extracted with ethyl acetate. The extract was washed with sodium chloride aqueous solution, dried over sodium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel with a mixture of chloroform and methanol as an eluent to give N-(4-diethylamino-2-butynyl)-2-cyclohexyl-2-hydroxy-2-phenylacetamide (74 mg).

후처리

  1. temperaturethe solution was refluxed for 20 minutes
  2. temperatureAfter being cooled
  3. extractionextracted with ethyl acetate
  4. washThe extract was washed with sodium chloride aqueous solution
  5. dry with materialdried over sodium sulfate
  6. customevaporated in vacuo
  7. customThe residue was purified by column chromatography on silica gel with a mixture of chloroform and methanol as an eluent

출처 및 근거

ORD 기록
ord-a366e5e07fcd47ab9411e032db897c9e
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05192779

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