1-chloro-2-fluoro-4-iodobenzene → 1-Chloro-2-fluoro-4-[(4-pentylphenyl)ethynyl]benzene

HRID 1613528노트

반응식

HRID 1613528 반응식
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([C:12]#[CH:13])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[F:14][C:15]1[CH:16]=[C:17](I)[CH:18]=[CH:19][C:20]=1[Cl:21]>Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Cu]I.C(NCC)C>[CH2:1]([C:6]1[CH:7]=[CH:8][C:9]([C:12]#[C:13][C:17]2[CH:18]=[CH:19][C:20]([Cl:21])=[C:15]([F:14])[CH:16]=2)=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

참가 물질

6

반응물 2

HCID 27365631-chloro-2-fluoro-4-iodobenzeneHCID 27751311-Ethynyl-4-pentylbenzene

생성물 1

HCID 157452301-Chloro-2-fluoro-4-[(4-pentylphenyl)ethynyl]benzene

시약·촉매·용매 3

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매HCID 178418476HCID 178418476, 화합물촉매HCID 8021Diethylamine용매

실험 절차

0.2 mmol of Pd(PPh3)2Cl2 and 0.1 mmol of CuI are added to a mixture of 0.01 mol of 4-pentylphenylacetylene, 0.01 mol of 3-fluoro-4-chloro-iodobenzene and 40 ml of diethylamine at room temperature and stirred for 12 hours. After completion of the reaction, the suspension is filtered, and the filtrate is concentrated by evaporation. Purification by chromatography and/or crystallization gives 4-pentyl-3'-fluoro-4'-chloro tolan having C 49.6° I.

후처리

  1. customAfter completion of the reaction
  2. filtrationthe suspension is filtered
  3. concentrationthe filtrate is concentrated by evaporation
  4. customPurification
  5. customby chromatography and/or crystallization

출처 및 근거

ORD 기록
ord-27b81805cbca4584a94a315c6f563575
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05194178

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