4-Methyl-5,6-dihydroquinoline → 5,6,7,8-tetrahydro-7-(N-hydroxy-1-propylamino)-4-methylquinoline

HRID 1613583노트

반응식

HRID 1613583 반응식
[CH3:1][C:2]1[C:11]2[CH2:10][CH2:9][CH:8]=[CH:7][C:6]=2[N:5]=[CH:4][CH:3]=1.Cl.[CH2:13]([NH:16][OH:17])[CH2:14][CH3:15]>CO>[OH:17][N:16]([CH2:13][CH2:14][CH3:15])[CH:8]1[CH2:7][C:6]2[N:5]=[CH:4][CH:3]=[C:2]([CH3:1])[C:11]=2[CH2:10][CH2:9]1

참가 물질

4

반응물 2

HCID 121336204-Methyl-5,6-dihydroquinolineHCID 12355438N-propylhydroxylamine hydrochloride

생성물 1

HCID 148359505,6,7,8-tetrahydro-7-(N-hydroxy-1-propylamino)-4-methylquinoline수율 73.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

This compound was prepared from the product of Step 6 (4.5 g, 30 mmol), 1-propylhydroxylamine hydrochloride (6 g, 55 mmol), and methanol (20 ml) by the method outlined in Example 10. The crude material was recrystallised from cyclohexane to give the product (4.85 g).

후처리

  1. customThe crude material was recrystallised from cyclohexane

출처 및 근거

ORD 기록
ord-e083ec29763c4624be6072bb433d1a81
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05194439

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