Benzyl Alcohol → Benzyl sulfamate

반응식

[S:1](Cl)(=[O:4])(=[O:3])[NH2:2].[CH2:6]([OH:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[S:1]([O:13][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:4])(=[O:3])[NH2:2]

참가 물질

반응물 2

HCID 244Benzyl Alcohol

HCID 24499Chlorosulfamic acid

생성물 1

HCID 9990000Benzyl sulfamate수율 38%

실험 절차

The title compound was prepared by the procedures of Example 33 from sulfamoyl chloride and benzyl alcohol being careful to use reduced pressure at about 35° C. to remove solvents in order to avoid violent decomposition observed in another trial at higher temperature. A white solid, mp 75°-78° C., was obtained in 38% yield.

후처리

customat about 35° C.
customto remove solvents in order
customA white solid, mp 75°-78° C., was obtained in 38% yield

출처 및 근거

ORD 기록: ord-98549ebc5a644c70a0efd1f1ff437bbc
출처 데이터셋: uspto-grants-1993_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05194446

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