Methanol → 4-Methyl-7-propyl-1H-indene

HRID 1613915노트

반응식

HRID 1613915 반응식
C[O-].[Na+].CO.[CH3:6][C:7](=O)[CH2:8][CH2:9][C:10](=O)[CH2:11][CH2:12][CH3:13].[CH:16]1[CH2:20][CH:19]=[CH:18][CH:17]=1>>[CH3:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:11][CH2:12][CH3:13])=[C:16]2[C:17]=1[CH:18]=[CH:19][CH2:20]2

참가 물질

5

반응물 4

HCID 887MethanolHCID 7612CyclopentadieneHCID 64203992,5-OctanedioneHCID 10942334Sodium Methoxide

생성물 1

HCID 187834694-Methyl-7-propyl-1H-indene수율 39.5%

실험 절차

45 ml of a 30 percent strength solution of sodium methanolate in methanol (250 mmol) were initially introduced into the reaction vessel at 0° C., and a mixture of 14.2 g (100 mmol) of 2,5-octanedione and 9 ml (110 mmol) of cyclopentadiene was added in the course of 30 minutes. After the mixture had been stirred at room temperature for 3 hours, it was poured into 300 ml of ice-water and extracted with diethyl ether and the organic phase was dried over magnesium sulfate. The residue which remained after evaporation was chromatographed on silica gel. 6.8 g (39%) of the indene 2 could be isolated with hexane as the mobile phase.

후처리

  1. additionwas added in the course of 30 minutes
  2. extractionextracted with diethyl ether
  3. dry with materialthe organic phase was dried over magnesium sulfate
  4. customafter evaporation
  5. customwas chromatographed on silica gel

출처 및 근거

ORD 기록
ord-cf407bff8f754ea5a2df81568822819b
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05194619

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