Trifluoroacetic acid → HCID 178480378, 화합물

HRID 1614063노트

반응식

HRID 1614063 반응식
[I-].C(OC([NH:9][C@@H:10]1[C:40](=[O:41])[N:12]2[C:13]([C:24]([O:26]C(C3C=CC=CC=3)C3C=CC=CC=3)=[O:25])=[C:14]([CH2:17][N+:18]3[N:19]([CH3:23])[CH:20]=[CH:21][CH:22]=3)[CH2:15][S:16][C@H:11]12)=O)(C)(C)C.C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O.C(OC(C)C)(C)C>C(Cl)Cl>[NH2:9][C@@H:10]1[C:40](=[O:41])[N:12]2[C:13]([C:24]([O-:26])=[O:25])=[C:14]([CH2:17][N+:18]3[N:19]([CH3:23])[CH:20]=[CH:21][CH:22]=3)[CH2:15][S:16][C@H:11]12

참가 물질

6

반응물 4

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 7914Diisopropyl EtherHCID 178480376HCID 178480376, 화합물

생성물 1

HCID 178480378HCID 178480378, 화합물수율 176.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of benzhydryl 7β-tert-butoxycarbonylamino-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate iodide (22.3 g) and anisole (22 ml) in methylene chloride (66 ml) was added trifluoroacetic acid (44 ml) under ice-cooling. After the mixture was stirred at ambient temperature for an hour, the reaction mixture was added dropwise to diisopropyl ether (600 ml). The resultant precipitates were collected by filtration to give bis(trifluoroacetic acid) salts of 7β-amino-3-(2-methyl-1-pyrazolio)methyl-3-cephem-4-carboxylate (16.83 g).

후처리

  1. temperaturecooling
  2. customThe resultant precipitates
  3. filtrationwere collected by filtration

출처 및 근거

ORD 기록
ord-18051330a6104fa39a3890831faaa6be
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05194432

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