Urea → HCID 19101100, 화합물

HRID 1614177노트

반응식

HRID 1614177 반응식
[CH3:1][C:2]([CH3:14])([C:4](=[O:13])[CH:5](Br)[C:6](=O)[C:7]([CH3:10])([CH3:9])[CH3:8])[CH3:3].[NH2:15][C:16]([NH2:18])=[O:17]>CN(C=O)C>[NH2:18][C:16]1[O:17][C:5]([C:4](=[O:13])[C:2]([CH3:14])([CH3:3])[CH3:1])=[C:6]([C:7]([CH3:10])([CH3:9])[CH3:8])[N:15]=1

참가 물질

4

반응물 2

HCID 1176UreaHCID 546382Bromo-dipivaloylmethane

생성물 1

HCID 19101100HCID 19101100, 화합물수율 42.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2,2,6,6-tetramethyl-4-bromo-3,5-heptanedione (70 g) and urea (77 g) in DMF (500 mL) is heated at 110°-120° C. overnight. The reaction mixture is cooled and poured into ice water (1500 mL) and the resulting precipitate is collected by filtration and air dried. The solid is rinsed with hexane (1000 mL) and then with isopropyl ether (200 mL) and dried under vacuum overnight to give 1-[2-amino-4-(1,1-dimethylethyl)-5-oxazolyl]-2,2-dimethyl-1-propanone (25.5 g, 42%); mp 248°-250° C.

후처리

  1. temperatureis heated at 110°-120° C. overnight
  2. temperatureThe reaction mixture is cooled
  3. filtrationthe resulting precipitate is collected by filtration and air
  4. customdried
  5. washThe solid is rinsed with hexane (1000 mL)
  6. dry with materialwith isopropyl ether (200 mL) and dried under vacuum overnight

출처 및 근거

ORD 기록
ord-03e39079bec64e41938e576d27c33df8
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05196431

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