5-bromo-1,2 dihydro-2,2-dimethyl-6-(2-imidazolin-2-ylamino)-3-(4H)-quinoxalinone → HCID 15225709, 화합물

HRID 1614549노트

반응식

HRID 1614549 반응식
[Br:1][C:2]1[C:11]([NH:12][C:13]2[NH:14][CH2:15][CH2:16][N:17]=2)=[CH:10][CH:9]=[C:8]2[C:3]=1[NH:4][C:5](=O)[C:6]([CH3:19])([CH3:18])[NH:7]2>O1CCCC1>[Br:1][C:2]1[C:11]([NH:12][C:13]2[NH:14][CH2:15][CH2:16][N:17]=2)=[CH:10][CH:9]=[C:8]2[C:3]=1[NH:4][CH2:5][C:6]([CH3:19])([CH3:18])[NH:7]2

참가 물질

3

반응물 1

HCID 152257155-bromo-1,2 dihydro-2,2-dimethyl-6-(2-imidazolin-2-ylamino)-3-(4H)-quinoxalinone

생성물 1

HCID 15225709HCID 15225709, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

A suspension of 5-bromo-1,2-dihydro-2,2-dimethyl-6-(2-imidazolin-2-ylamino)-3-(4H)-quinoxalinone (150 mg, 0.45 mmol) and LiALH4 (17 mg, 0.45 mmol) in tetrahydrofuran (3 ml) is heated and maintained at a temperature of 50°-80° C. until the starting material is consumed. The mixture is cooled to 0° C., 2-3 drops of H2O is added and the mixture is filtered. The solution is concentrated in vacuo to yield a residue which is chromatographed on silica gel with CHCl3 : CH3OH saturated with NH3 (g) elution to produce the title compound.

후처리

  1. temperatureis heated
  2. temperaturemaintained at a temperature of 50°-80° C. until the starting material
  3. customis consumed
  4. addition2-3 drops of H2O is added
  5. filtrationthe mixture is filtered
  6. concentrationThe solution is concentrated in vacuo
  7. customto yield a residue which
  8. customis chromatographed on silica gel with CHCl3
  9. washCH3OH saturated with NH3 (g) elution

출처 및 근거

ORD 기록
ord-4b11abdaa5744cae8ae344110d4923ba
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05198442

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