Chloride → HCID 20095459, 화합물

HRID 1614573노트

반응식

HRID 1614573 반응식
[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH3:11])=[CH:6][CH:5]=1.[C:12](=[O:15])([O-])[O-].[K+].[K+].[Cl-]>CC(C)=O.O>[C:12]([N:2]([CH3:1])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH3:11])=[CH:6][CH:5]=1)(=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

6

반응물 3

HCID 312ChlorideHCID 11430Potassium CarbonateHCID 2452234N-Methyl-1-[4-(methylsulfanyl)phenyl]methanamine

생성물 1

HCID 20095459HCID 20095459, 화합물수율 199.6%

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매2회

실험 절차

N-Methyl-N-(4-methylthiobenzyl)amine (4.2 g) and potassium carbonate (5.2 g) are dissolved in a mixture of acetone (20 ml) and water (20 ml), and thereto is added dropwise benzoy chloride (3.7 ml) gradually under ice cooling. After the mixture is stirred at the same temperature for 30 minutes, the reacting mixture is poured into water, and then extracted with dichloromethane. The extract is washed with aqueous sodium chloride solution, and dried over magnesium sulfate. Dichloromethane is distilled off to give N-benzoyl-N-methyl-N-(4-methylthiobenzyl)amine (6.8 g).

후처리

  1. extractionextracted with dichloromethane
  2. washThe extract is washed with aqueous sodium chloride solution
  3. dry with materialdried over magnesium sulfate
  4. distillationDichloromethane is distilled off

출처 및 근거

ORD 기록
ord-e693d1bea73b4058a0d5a8ba57e57816
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05198448

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