Borane → (2-Bromo-5-methoxyphenyl)methanamine

HRID 1614967

반응식

HRID 1614967 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[C:4]#[N:5].B>O1CCCC1>[Br:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH2:4][NH2:5]

참가 물질

4

반응물 2

HCID 6331BoraneHCID 217840962-Bromo-5-methoxybenzonitrile

생성물 1

HCID 24691009(2-Bromo-5-methoxyphenyl)methanamine수율 36%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

2-Bromo-5-methoxybenzonitrile (10.0 g, 47.2 mmol) was dissolved in dry tetrahydrofuran (100 mL) in a flame-dried flask and cooled in an ice bath. A solution of borane in tetrahydrofuran (75 mL, 75 mmol, 1.0 M) was added dropwise over a period of 30 minutes. The reaction mixture was stirred overnight at rt, then quenched slowly with ice water and Na2CO3 (saturated aqueous solution). After removal of THF, the residue was extracted with large amounts of EtOAc three times. The combined organic layers were washed with water, dried, and concentrated to give the crude, which was purified by silica gel column chromatography to give the desired product as a white powder (3.65 g, 36%). LCMS for C8H10BrNO (M+H)+: m/z=216.9, 219.0.

후처리

  1. temperaturecooled in an ice bath
  2. customquenched slowly with ice water and Na2CO3 (saturated aqueous solution)
  3. customAfter removal of THF
  4. extractionthe residue was extracted with large amounts of EtOAc three times
  5. washThe combined organic layers were washed with water
  6. customdried
  7. concentrationconcentrated
  8. customto give the crude, which
  9. customwas purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-16a1b52403504369b3559284ecc970ba
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765727B2

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