Water → HCID 59633913, 화합물

HRID 1615061노트

반응식

HRID 1615061 반응식
[I:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([O:9][CH3:10])[CH:3]=1.C([O-])([O-])=O.[K+].[K+].[CH2:17]([C:19]1[CH:26]=[CH:25][C:22]([CH2:23]Cl)=[CH:21][CH:20]=1)[CH3:18].O>CN(C=O)C>[CH2:17]([C:19]1[CH:26]=[CH:25][C:22]([CH2:23][O:8][C:5]2[CH:6]=[CH:7][C:2]([I:1])=[CH:3][C:4]=2[O:9][CH3:10])=[CH:21][CH:20]=1)[CH3:18]

참가 물질

6

반응물 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 738434-Ethylbenzyl chlorideHCID 101061274-Iodo-2-methoxyphenol

생성물 1

HCID 59633913HCID 59633913, 화합물수율 87%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

To a solution of 4-iodo-2-methoxyphenol (90 g) in DMF (450 mL) were added K2CO3 (60 g) and 4-ethylbenzyl chloride (58 g) at RT. The reaction mixture was stirred at 80° C. for 3 hr. Water (900 mL) was added to the reaction mixture. The precipitated solid was collected on a filter and dried under reduced pressure. The suspension of this solid in heptane (520 mL) was stirred at RT. The precipitated solid was collected on a filter and dried under reduced pressure to give the title compound (115 g, 87%).

후처리

  1. customThe precipitated solid was collected on
  2. filtrationa filter
  3. customdried under reduced pressure
  4. additionThe suspension of this solid in heptane (520 mL)
  5. stirringwas stirred at RT
  6. customThe precipitated solid was collected on
  7. filtrationa filter
  8. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-b974f25500f94a3a8049a6ef4e19be96
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765739B2

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