Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(S)-1-(3,4-Difluorophenyl)ethanamine → 9-{2-[(S)-1-(3,4-Difluoro-phenyl)-ethylamino]-ethyl}-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecan-9-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (S)-1-(3,4-Difluorophenyl)ethanamine | HCID 7016601 | — |
| 반응물 | (9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde | HCID 86668369 | — |
| 생성물 | 9-{2-[(S)-1-(3,4-Difluoro-phenyl)-ethylamino]-ethyl}-3,3-dimethyl-1,5-dioxa-spiro[5.5]undecan-9-ol | HCID 67996346 | 54% |
반응 단계
The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-(3,4-difluoro-phenyl)-ethylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 54% of theory; LC (method 5): tR=1.00 min; Mass spectrum (ESI+): m/z=384 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08765744B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-92ea6f01d08c4452b87939a77e7e051e |
| 출처 메모 | uspto-grants-2014_07 |