Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylsulphamoyl chloride → N,N-dimethyl-N'-(2-oxo-2,3-dihydro-1H-indol-5-yl)sulfamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylsulphamoyl chloride | HCID 83372 | — |
| 반응물 | 5-Amino-2-oxindole | HCID 2773213 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | N,N-dimethylformamide ethyl acetate | HCID 22989253 | — |
| 생성물 | N,N-dimethyl-N'-(2-oxo-2,3-dihydro-1H-indol-5-yl)sulfamide | HCID 69812379 | 32.3% |
반응 단계
To 5-aminoindolin-2-one (100 mg, 0.68 mmol) in ethyl acetate/DMF 1:1 (2 mL) was added dimethylsulfamoyl chloride (290 mg, 2.04 mmol) and DMAP (1 mg). After 72 h the product was precipitated with ether, filtered and dried to give 56 mg, 32% of a white solid. 1H NMR (400 MHz, CD3OD) δ 7.21 (s, 1H), 7.16 (d, J=7.0 Hz, 1H), 7.00 (d, J=8.0 Hz, 1H), 3.53 (s, 2H), 2.77 (s, 6H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08765748B2 |
| 출처 데이터셋 | uspto-grants-2014_07 |
| ORD ID | ord-9de4efba5023491ca359db0caef9324f |
| 출처 메모 | uspto-grants-2014_07 |