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6-(3-(Pyrrolidin-1-yl)prop-1-ynyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine → 6-(3-(Pyrrolidin-1-yl)propyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine

HRID 1615462
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HRID 1615462 반응식
[N:1]1([CH2:6][C:7]#[C:8][C:9]2[CH:10]=[C:11]3[N:16]([CH:17]=2)[N:15]=[CH:14][N:13]=[C:12]3[NH2:18])[CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>[Pd].CO>[N:1]1([CH2:6][CH2:7][CH2:8][C:9]2[CH:10]=[C:11]3[N:16]([CH:17]=2)[N:15]=[CH:14][N:13]=[C:12]3[NH2:18])[CH2:2][CH2:3][CH2:4][CH2:5]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 706652016-(3-(Pyrrolidin-1-yl)prop-1-ynyl)pyrrolo[2,1-f][1,2,4]triazin-4-amineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 666017846-(3-(Pyrrolidin-1-yl)propyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine수율 91.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

In a round-bottom flask, the compound (269 mg, 1.14 mmol) prepared in Example 11, palladium/carbon (10%, 20 mg) and methanol (10 mL) was added and the atmosphere was replaced with hydrogen gas at 1 atm. After 18 hours, the mixture was filtered through celite and the celite pad was washed with methanol. The methanol was removed in vacuo to obtain the title compound (257 mg) having the following physical data.

후처리

  1. filtrationthe mixture was filtered through celite
  2. washthe celite pad was washed with methanol
  3. customThe methanol was removed in vacuo

출처 및 근거

ORD 기록
ord-a86885829d8b4346a7ed282ac13f5d9d
출처 데이터셋
uspto-grants-2014_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08765754B2

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