Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1615659생성일: 2026년 10월 27일
1,7-Naphthyridin-8-amine → 8-imino-1,7-naphthyridin-7(8H)-amine 2,4,6-trimethylbenzenesulfonate
https://huagongshe.com/reaction/1615659
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,7-Naphthyridin-8-amine | HCID 2737037 | — |
| 반응물 | O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine | HCID 11830845 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 8-imino-1,7-naphthyridin-7(8H)-amine 2,4,6-trimethylbenzenesulfonate | HCID 86667814 | 80.8% |
반응 단계
To a solution of 1,7-naphthyridin-8-amine (600 mg, 4.13 mmol) in DCM (5 mL) was added a solution of O-(mesitylsulfonyl)hydroxylamine (2.7 g, 12.4 mmol) in DCM (10 mL) at 0° C. The mixture was stirred at 0° C. for 2 h. The precipitate was filtered and collected to give 8-imino-1,7-naphthyridin-7(8H)-amine-2,4,6-trimethylbenzenesulfonate as a brown solid (1.2 g, yield 67%). ESI MS: m/z 161.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08765760B2 |
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| 출처 데이터셋 | uspto-grants-2014_07 |
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| ORD ID | ord-18fb3b174db0468e8091f39ecf0e2911 |
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| 출처 메모 | uspto-grants-2014_07 |
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