Water → Imidazo(1,2-a)pyridine-2-carbaldehyde
반응식
[N:1]1[C:2]([CH2:10][OH:11])=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.O>CCO.[O-2].[Mn+4].[O-2]>[N:1]1[C:2]([CH:10]=[O:11])=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12참가 물질
5
실험 절차
To a solution of imidazo[1,2-a]pyridin-2-ylmethanol (3.0 g, 20 mmol) in EtOH (50 mL) was added manganese (IV) oxide (8.8 g, 100 mmol). The mixture was refluxed for 2 days. After cooling to room temperature, the mixture was filtered through Celite, and the filtrate was concentrated. The residue was purified by reverse phase column chromatography (eluting with acetonitrile in water 25% v/v, with 0.01% NH3. H2O) to afford the title compound (0.45 g, 15% yield) as a yellow solid. ESI MS: m/z 147 [M+H]+.
후처리
- temperatureThe mixture was refluxed for 2 days
- filtrationthe mixture was filtered through Celite
- concentrationthe filtrate was concentrated
- customThe residue was purified by reverse phase column chromatography (
- washeluting with acetonitrile in water 25% v/v
출처 및 근거
- ORD 기록
- ord-4a19075232f043c2b488e9527d3f5541
- 출처 데이터셋
- uspto-grants-2014_07
- 특허 번호
- US08765760B2
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