Ammonium Chloride → 2-Azido-4-((3-phenylpropyl)amino)nicotinonitrile

HRID 1615907노트

반응식

HRID 1615907 반응식
Br[C:2]1[N:9]=[CH:8][CH:7]=[C:6]([NH:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:3]=1[C:4]#[N:5].[N-:20]=[N+:21]=[N-:22].[Na+].[Cl-].[NH4+]>CN(C=O)C>[N:20]([C:2]1[N:9]=[CH:8][CH:7]=[C:6]([NH:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:3]=1[C:4]#[N:5])=[N+:21]=[N-:22]

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 866965062-Bromo-4-((3-phenylpropyl)amino)nicotinonitrile

생성물 1

HCID 866965072-Azido-4-((3-phenylpropyl)amino)nicotinonitrile수율 91.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Prepared according to the methods above using 2-bromo-4-((3-phenylpropyl)amino)nicotinonitrile (43.6 mg, 0.138 mmol), sodium azide (17.93 mg, 0.276 mmol) and ammonium chloride (14.75 mg, 0.276 mmol) in DMF (0.5 mL) at 100° C. for 18 hours to give the desired product as a yellow oil (35 mg). LC/MS (277, [M−H]−). This material was used as is.

후처리

  1. customPrepared
  2. customat 100° C.
  3. customfor 18 hours

출처 및 근거

ORD 기록
ord-e068fc80cce74db9a8380a072880a662
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765767B2

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