Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isobutyl isothiocyanate → trans-N-(7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-yl)-N'-(2-methylpropyl)thiourea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isobutyl isothiocyanate | HCID 68960 | — |
| 반응물 | trans-7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepine-1-amine | HCID 70883458 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | trans-N-(7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-yl)-N'-(2-methylpropyl)thiourea | HCID 86599868 | 12% |
반응 단계
Isobutyl isothiocyanate (3.35 mg, 0.03 mmol) was added to trans-7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepine-1-amine (5 mg, 0.02 mmol) in 1 mL of THF. The resulting mixture was stirred at room temperature for 18 h. The mixture was evaporated under reduced pressure. Crystallisation from methanol gave trans-N-(7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-yl)-N′-(2-methylpropyl)thiourea (1 mg, 12%). Data: (m/z)=416 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737136B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-1d851d7ba4c147f5b6c7b8ee51973cf0 |
| 출처 메모 | uspto-grants-2010_06 |